Prophylaxis and therapeutic potentials of ozone in buiatrics

What is it about?

The ozone therapy has been in use since 1896 in the USA. As a highly reactive molecule ozone may inactivate bacteria, viruses, fungi, yeasts and protozoans, stimulate oxygen metabolism of tissues, treat diseases, activate the immune system and exhibit strong analgesic activity. More recently ozone has found use in veterinary medicine, particularly in buiatrics, but still insufficiently since medical ozone therapy showed effectiveness as an alternative to the use of antibiotics which are restricted to clinical use and withdrawn in nonclinical use as in-feed growth promoters in animal production. This review compiles the current knowledge regarding preventive and therapeutic effects of ozone in ruminants for the treatment of puerperal diseases and improvement of their fertility. In particular, ozone preparations were tested in treatment of reproductive tract lesions, urovagina and pneumomovagina, metritis, endometritis, foetal membrane retention and mastitis as well as in functional restoration of endometrium in dairy cows and goats. Also, the preventive use of intrauterine application of ozone was assessed in order to evaluate its effectiveness to improve the reproductive efficiency in dairy cows.Moreover, there were a lot of facts indicating the advantages of the therapy by ozone preparations in comparison to the antibiotics applied. However, there are certain limitations of ozone use in veterinary medicine and buiatrics such as: inactivity against intracellular microbes and selective activity against same bacterial species as well as the induction of tissue inflammation by inappropriate application of the preparation.

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