What is it about?
Hypertriglyceridemia is associated with an increased risk of cardiovascular disease. The potential favorable effects of artichoke leaf extract (ALE) on anthropometric and metabolic indices may affect by fat mass and obesity associated (FTO)-rs9939609 polymorphism. This study was designed to evaluate the effects of ALE supplementation on cardiometabolic risk factors in hypertriglyceridemic patients regarding the interaction of rs9939609-FTO polymorphism with intervention outcomes.
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Why is it important?
No significant effect of ALE supplementation was shown on anthropometric and biochemical indices in Iranian hypertriglyceridemic patients. However, rs9939609 variant of FTO gene seems to affect lipid profile response to ALE supplementation.
Perspectives
Further clinical trials with larger sample size are suggested to clarify the possible interaction between rs9939609 variant or other variants of FTO gene and ALE supplementation in hypertriglyceridemia.
Khatereh Rezazadeh
Nutrition Research Center, School of Nutrition & Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
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This page is a summary of: The interaction of FTO-rs9939609 polymorphism with artichoke leaf extract effects on cardiometabolic risk factors in hypertriglyceridemia: A randomized clinical trial, Advances in Integrative Medicine, August 2018, Elsevier,
DOI: 10.1016/j.aimed.2018.08.006.
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