What is it about?
This study investigates the roles of PAR-1 and MMP-1 in the progression and prognosis of gastric cancer, aiming to assess their potential as biomarkers and therapeutic targets. By analyzing clinical samples and correlating expression levels of PAR-1 and MMP-1 with patient outcomes, the research demonstrates that elevated expression of these proteins is significantly associated with advanced disease stages, increased invasiveness, and poorer survival. The study highlights the prognostic value of PAR-1 and MMP-1 and proposes their potential utility in the development of targeted therapies to improve the management of gastric cancer.
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Why is it important?
Gastric cancer remains one of the leading causes of cancer-related death worldwide, often diagnosed at advanced stages where prognosis is poor and treatment options are limited. Identifying reliable prognostic biomarkers and novel therapeutic targets is essential for improving early detection, guiding treatment decisions, and developing more effective therapies. This study is important because it provides strong evidence that PAR-1 and MMP-1 are significantly associated with gastric cancer progression and patient survival. By highlighting their potential as prognostic factors and therapeutic targets, the research opens new avenues for precision medicine approaches aimed at improving outcomes for patients with gastric cancer.
Perspectives
The study identifies PAR-1 and MMP-1 as promising prognostic biomarkers for gastric cancer progression and survival. It highlights the potential of targeting PAR-1 and MMP-1 in the development of novel gastric cancer therapies. The findings contribute to advancing precision medicine approaches for better management of gastric cancer.
Dr.Ramakrishnan Veerabathiran
Chettinad Health City
Read the Original
This page is a summary of: Protease activator receptor-1 and matrix metalloproteinase-1 as prognostic factors and a novel therapeutic targets for gastric cancer, January 2025, Elsevier,
DOI: 10.1016/b978-0-443-30098-1.00012-4.
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