What is it about?
Medicines change our cells. There are thousands of such substances and one cannot test all in single petri dishes. Therefore miniaturised dishes are used, where cells are treated with compounds and microscopic photos are taken. There are many thousands of those photos, containing millions of cells. This chapter overviews how to do those experiments and use computer image processing to measure those cells.
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Why is it important?
A medicine is effective when it produces the desired changes in cells. How to find the most effective medicine in drug discovery, when we have thousands of those compounds, millions of cells and the desired change is so fine, hardly detectable by a microscope? Robotics and automated computer image processing can only cope with the sheer number of cellular measurements when treated with multi thousand compounds.
Perspectives
Computer image processing is essential in measurement how medicines change cells. What software to choose? What are the steps of data analysis? This overview gives an insight for the drug designer chemist, biochemist and biologist, to the software world of high-content analysis.
Dr Janos KristonVizi
University College London
Read the Original
This page is a summary of: High-Content Screening in Cell Biology, January 2016, Elsevier,
DOI: 10.1016/b978-0-12-394447-4.40041-6.
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