What is it about?
GC is an excellent separation technique that resolves analytes chromatographically based on their volatility and polarity. MS detects the ions and generates mass spectrum for each analyte, and this structural information aids in its identification. The synergistic coupling of GC and MS renders the tandem technique a major analytical workhorse in metabonomics.
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Perspectives
GC/MS is an indispensible analytical tool widely employed in metabonomics. The fastgrowing number of publications released each year on GC/MS metabonomics is a good indicator of the emerging popularity of its application. The extension of its application from small-scale studies to larger-scale (epidemiological) studies to answer biological questions clearly testifies to the technical maturity of GC/MS in metabonomics. Although certain challenges such as variation from derivatization and metabolite identification remain to be resolved, it is heartening to observe researchers exploring innovative strategies to overcome the challenges imposed by analytical constraints such as analytical drift. Such relentless efforts would certainly elevate GC/MS-based metabonomics to greater heights in the near future.
Dr Eric Chun Yong Chan
National University of Singapore
Read the Original
This page is a summary of: Gas Chromatography/Mass Spectrometry-Based Metabonomics, January 2013, Elsevier,
DOI: 10.1016/b978-0-12-394446-7.00008-x.
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