What is it about?
Glucose is the dominant metabolic substrate for brain metabolism and its cerebral uptake is influenced by insulin. Thus, large doses of insulin combined with normo-glycemic clamp increases the glucose flux across the blood.brain barrier, but not the net uptake. The flux increases in both directions, and the net uptake remains unchanged.
Featured Image
Why is it important?
Insulin has an effect on (increases) the transport on glucose between the blood and the cerebral tissue. Glucose is essential for the cerebral function and the main cerebral energy supply.
Perspectives
Glucose is by far the dominant metabolic substrate of the brain. The blood-brain barrier is impermeable for most hydrophilic substances. But glucose, essential for the brain, is transported with a mechanism of facilitated diffusion.
Professor Olaf B Paulson
University of Copenhagen
Read the Original
This page is a summary of: INSULIN AND THE BLOOD-BRAIN BARRIER, January 1981, Elsevier,
DOI: 10.1016/b978-0-08-026819-4.50036-2.
You can read the full text:
Contributors
The following have contributed to this page
