What is it about?
Phorbol ester (PMA) exerted a dose- and time- dependent stimulating effect on phagocytosis in axenic (i.e. cultured in sterile medium) Paramecium aurelia. When cells were exposed to 200–800 nM PMA in the presence of latex beads, the phagocytic coefficient was enhanced 2.25 to 3.14 times, during 10 min of continous treatment and then rapidly declined. A similar effect was observed when the cells were exposed to a forskolin treatment, which resulted in nearly a twofold increase in phagocytic activity after a 10 min pulse.
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Why is it important?
Both PMA and forskolin strongly stimulated phagocytosis (i.e. fivefold and threefold, respectively) in cells in which such activity had been completely inhibited by pre-exposure to the beta-receptor antagonist l-propranolol.
Perspectives
It is reasonable to suppose that the results obtained may be due to activation of beta-adrenergic receptor-linked adenylate cyclase system which appears to be involved in Paramecium phagocytosis.
Professor Elzbieta Wyroba
Nencki Institute of Experimental Biology
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This page is a summary of: Stimulation of phagocytosis by phorbol ester and forskolin, Cell Biology International Reports, September 1987, Wiley,
DOI: 10.1016/0309-1651(87)90100-7.
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