What is it about?
A peripherally acting and a centrally acting 5-HT2 antagonist were compared for their ability to block morphine analgesia. The centrally acting antagonist was more potent and efficacious.
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Why is it important?
This eliminated the possibility that the 5-HT2 receptors that mediate morphine analgesia are in the peripheral nervous system.
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This page is a summary of: Attenuation of morphine analgesia by the S2 antagonists, pirenperone and ketanserin, Pharmacology Biochemistry and Behavior, November 1988, Elsevier,
DOI: 10.1016/0091-3057(88)90243-2.
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