What is it about?
Whole fetal tissue transplants survived in the host rat brain but did not extend or receive axonal connections to or from the host brain.
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Why is it important?
At the time this was one of the first connectivity studies on transplants designed to improve outcome in an animal model of Huntington's disease. The results showed that a glial scar encapsulated the transplanted tissue and prevented afferent and efferent connections from developing.
Perspectives
This study was initiated during an exciting time because patients with Parkinson's and Huntington's disease were going to Mexico for transplant surgery even though the basic science experiments had not been conducted to validate the clinical procedure. It was also very rewarding to conduct this work with my first graduate student, Dr. Paul Walker.
James McAllister
Washington University in St. Louis School of Medicine
Read the Original
This page is a summary of: Minimal connectivity between neostriatal transplants and the host brain, Brain Research, November 1987, Elsevier,
DOI: 10.1016/0006-8993(87)90480-x.
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