What is it about?

Alkylating agents have in common the ability to damage DNA and/or impair DNA replication. Sulfur mustard, like other alkylating agents, has systemic toxicity to the cells of bone marrow, lymphoid tissue, gut mucosa, and germinal epithelium. Mustard gas can cause defective spermatogenesis years after exposure.

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Why is it important?

Reactions with DNA have been considered the most significant injury to cells from mustard, and these reactions, as well as their consequences, are by far the most widely studied after mustard exposure.


Spermatozoa from infertile men have a higher frequency of chromosomal abnormalities, poor DNA packing quality (18), increased DNA strand breaks and susceptibility to acid-induced DNA denaturation in situ than spermatozoa from fertile men.

Dr Mohammad Reza Safarinejad
University of Medical Sceices

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This page is a summary of: Testicular effect of mustard gas, Urology, July 2001, Elsevier,
DOI: 10.1016/s0090-4295(01)01085-8.
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