Phosphatidylinositol 4-kinases: Function, structure, and inhibition

  • Evzen Boura, Radim Nencka
  • Experimental Cell Research, October 2015, Elsevier
  • DOI: 10.1016/j.yexcr.2015.03.028

Phosphatidylinositol 4-kinase - review article

What is it about?

Here we summarize the development in the field of phosphatidylinositol 4-kinases (PI4Ks). PI4Ks are enzymes that produce a key lipid - phosphatidylinositol 4-phosphate (PI4P).

Why is it important?

PI4Ks are hijacked by several +RNA viruses and the inhibition of PI4Ks leads to the arrest of viral replication. Thus, PI4Ks are recognized as a potential target for antivirals.

Perspectives

Evzen Boura
Institute of Organic Chemistry and Biochemistry

I hope this article provides a comprehensive yet concise overview of the PI4K field.

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http://dx.doi.org/10.1016/j.yexcr.2015.03.028

The following have contributed to this page: Evzen Boura