What is it about?
Atheroclerotic change was investigated in LDL and apoE double knockout mice.
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Why is it important?
Endothelial functional change comes out prior to morphological one in atherosclerosis
Perspectives
Concomitant measurement with shear-induced thrombosis test using non-anticoagulated blood and endothelial function test using flow-mediated vasodilation is beneficial to prevent and treatment of atherothrombotic diseases.
Junichiro Yamamoto
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This page is a summary of: Endothelial dysfunction precedes atherosclerotic lesions and platelet activation in high fat diet-induced prothrombotic state, Thrombosis Research, January 2006, Elsevier, DOI: 10.1016/j.thromres.2005.04.022.
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