What is it about?
The identified abundant putative AREs will define the Keap1-Nrf2-ARE network and elucidate the precise regulation of Nrf2-ARE pathway in not only diseases but also in embryonic development, inflammation, and aerobic respiration.
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Why is it important?
Our in silico findings suggest that TGAG/CNNNTC ARE motifs were found to be abundant than TGAG/CNNNGC ARE motifs in the antioxidant genes and in all protein coding genes of zebrafish.
Perspectives
These AREs detected here will elucidate the precise regulation of Nrf2-ARE pathway in not only the diseases but also in embryonic development, inflammation, and aerobic respiration.
Dr Azhwar Raghunath
University of Michigan
Read the Original
This page is a summary of: Genome-wide identification and analysis of Nrf2 binding sites – Antioxidant response elements in zebrafish, Toxicology and Applied Pharmacology, December 2018, Elsevier,
DOI: 10.1016/j.taap.2018.09.013.
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