What is it about?
We evaluated the effects of opiate consumption on semen quality, sperm function, seminal plasma antioxidant capacity, and sperm DNA integrity.
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Why is it important?
Addiction to mind altering and recreational drugs is increasingly becoming a major worldwide medical and social problem that is prevalent in rich and poor countries similarly. A considerable number of male factor infertility is categorized as “idiopathic” due to unknown etiology. In clinical practice, we regularly encounter men with poor semen quality, who are taking opiate and/or recreational substances. Endogenous opioid peptides are present in various tissues of the male reproductive tract, suggesting that they may be involved in the reproductive function. Several studies have demonstrated the deleterious effects of opiate compounds on sperm cell motility and morphology. It has been demonstrated that opiate abuse may result in hypogonadism, primarily by decreasing release of gonadotropin-releasing hormone (GnRH).
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This page is a summary of: The effects of opiate consumption on serum reproductive hormone levels, sperm parameters, seminal plasma antioxidant capacity and sperm DNA integrity, Reproductive Toxicology, April 2013, Elsevier, DOI: 10.1016/j.reprotox.2012.11.010.
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