What is it about?

Report on the isolation. characterisation and bioactvity of inophyllums, xanthones and other compounds found in the fruits of Callophyllum inophyllum. Bintangor and Nyamplung are the local names for Calophyllum species and this large bitter-sweet kernel greenish oil is used as liniment and valued for those who suffered from rheumatism, pains in the joints and bruises.

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Why is it important?

The inhibition of the crude extract on lipooxygenase and cyclooxygenase activities indicates its high anti-inflamatory activity. In-vitro assays demonstrated that the crude extract at concentration of 50 ug/ml inhibited 77% and 88% cyclooxygenase and lipooxygenase activities, respectively, indicating its potential as anti-inflamatory agent. This supported the traditional used of this oil for relieving pains.

Perspectives

In this study, 12 metabolites were isolated from the fruits of C. inophyllum. Based on our previous experiences, solvent extraction gave a gummy extract which complicates the separation of metabolites on column chromatography. However, boiling the nuts in hot water produces oil which separated out on the top layer. After cooling, the layer contains isoprenylatedcoumarins that can be easily separated by column chromatography. This is the traditional method of producing the oil used for medicinal ointment.

Zul Ilham
University of Malaya

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This page is a summary of: Anti-inflammatory Activity of Calophyllum Inophyllum Fruits Extracts, Procedia Chemistry, January 2014, Elsevier, DOI: 10.1016/j.proche.2014.12.031.
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