What is it about?
We have identified a mature miR-17-3p processed from the 3’-arm of precursor miR-17, which appeared to be able to inhibit three major antioxidant enzymes located in mitochondria, i.e. manganese superoxide dismutase (MnSOD), glutathione peroxidase 2 (Gpx2) and thioredoxin reductase 2 (TrxR2). Here, we show that up-regulation of miR-17-3p remarkably sensitized PCa cells to ionizing radiation.
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Why is it important?
The present study demonstrates that the manipulation of miR-17-3p supposedly affects the cellular redox status due to its ability of targeting antioxidants. In the context, the inactivation of antioxidants by expressing miR-17-3p should increase ROS and enhance radiotherapeutic efficiency to treat aggressive tumors. This study highlights the rigorous evidence that demonstrated suppression of multiple mitochondrial antioxidants by a single miRNA, thereby providing a promising approach to improve radiotherapy for advanced PCa by targeting mitochondrial function.
Perspectives
Our results provide proof-of-concept evidence that inhibition of mitochondrial function by targeting its antioxidant defense system contributes to radiosensitization in advanced PCa cells.
Jin-Hai Tang
Nanjing Medical University
Read the Original
This page is a summary of: miR-17-3p Downregulates Mitochondrial Antioxidant Enzymes and Enhances the Radiosensitivity of Prostate Cancer Cells, Molecular Therapy — Nucleic Acids, December 2018, Elsevier,
DOI: 10.1016/j.omtn.2018.08.009.
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