What is it about?
This manuscript reviews the extant literature for evidence of developmental neurotoxicity. We evaluated the amount of evidence available for chemicals that have been reported to alter brain development in test animals and/or humans.
Why is it important?
This information can be used for the development of a set of chemicals to assess which screening technologies and alternative testing techniques best predict potential neurotoxicity. Out of 400 chemicals reviewed, approximately 100 had evidence of developmental neurotoxicity. Of these 100 chemicals, 21 had evidence in human studies. These chemicals will be useful for testing and evaluating the new high-throughput screening assays.
Read the Original
This page is a summary of: Expanding the test set: Chemicals with potential to disrupt mammalian brain development, Neurotoxicology and Teratology, November 2015, Elsevier, DOI: 10.1016/j.ntt.2015.10.001.
You can read the full text:
Summary information on chemicals
Summary information for all chemicals listed as having evidence for DNT
List of chemicals evaluated.
this is a list of all chemicals that were evaluated as part of this project
Chemicals with data from a single laboratory.
This is a list of chemicals for which evidence of DNT was from only one research laboratory.
List of all references for all chemicals listed in supplemental files.
The following have contributed to this page