What is it about?

This manuscript reviews the extant literature for evidence of developmental neurotoxicity. We evaluated the amount of evidence available for chemicals that have been reported to alter brain development in test animals and/or humans.

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Why is it important?

This information can be used for the development of a set of chemicals to assess which screening technologies and alternative testing techniques best predict potential neurotoxicity. Out of 400 chemicals reviewed, approximately 100 had evidence of developmental neurotoxicity. Of these 100 chemicals, 21 had evidence in human studies. These chemicals will be useful for testing and evaluating the new high-throughput screening assays.

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This page is a summary of: Expanding the test set: Chemicals with potential to disrupt mammalian brain development, Neurotoxicology and Teratology, November 2015, Elsevier, DOI: 10.1016/j.ntt.2015.10.001.
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