What is it about?
The nuclear pore complex of eukaryotes, cilia, the centrosome, mitotic chromosomes, and the ribosome are structures comprehensively resolved for their protein complement with mechanisms solved and proposed through cryoEM and AI. The integration of comprehensive and accurate data sets now defines a molecular microscope with near-atomic resolution that can be applied to all cell structures to determine molecular mechanisms of biogenesis and function.
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Why is it important?
The pipeline to characterize quantitatively and comprehensively proteins in cell structures integrated with the imaging of these proteins by cryoEM and AI has been established with most technical hurdles overcome today. The integration of orthogonal approaches has the promise of a new era of molecular anatomy of the cell.
Perspectives
Progress from the pioneering imaging work of the last century to visualize cell structures to the quantitative imaging at near-atomic resolution of the proteins in the same structures has been noteworthy. From the pioneers of the last century to the talented investigators who have established an intergrated pipeline of proteomics, CryoEM, Cryo-tomography, and AI, progress has only begun.
Dr John J. M. Bergeron
McGill University
Read the Original
This page is a summary of: Proteomics Impact on Cell Biology to Resolve Cell Structure and Function, Molecular & Cellular Proteomics, May 2024, Elsevier,
DOI: 10.1016/j.mcpro.2024.100758.
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