What is it about?

Comparison of vitamin E and propionyl-L-carnitine, separately or in combination, in patients with early chronic Peyronie's disease: a double-blind, placebo controlled, randomized study.

Featured Image

Why is it important?

PD may dramatically affect sexual function as well as quality of life. Despite the numerous treatment options, a standard and worldwide accepted consensus for the medical treatment of PD has yet to be identified. Many oral medicines have been reported as having limited success in treating PD. These treatment options include vitamin E, potassium aminobenzoate, tamoxifen, colchicines, orgotein, procarbazine, systemic steroids and nonspecific antihistamines. Intralesional therapy for PD includes injection of steroids, calcium channel blocker, interferons, purified clostridial collagenase, parathyroid hormone and orgotein. Local therapies include ultrasound, shortwave diathermy, laser therapy, iontophoresis and extracorporeal shock wave therapy.


The preceding limited studies have demonstrated that carnitine is a reasonable option for the treatment of PD. In a nonrandomized and noncontrolled study Cavallini et al demonstrated that the combination of PLC and verapamil can be considered in the therapy of advanced and resistant PD. In another study it has been shown that acetyl-Lcarnitine is significantly more effective and safe than tamoxifen in the therapy of acute and early chronic PD. Most studies on treating PD with oral therapy compared variables before and after therapy using only 1 drug without a control arm. Thus, several drugs were recommended and later discarded. Cessation of all medical therapy at least 8 weeks before the initiation of the study was a washout period so that previous treatments had no effect when we started the study. The chance of spontaneous resolution (except of pain) is low and usually takes several years. Therefore, short-term variations in disease severity should help to distinguish the effects of drugs from spontaneous change.

Dr Mohammad Reza Safarinejad
University of Medical Sceices

Read the Original

This page is a summary of: Comparison of Vitamin E and Propionyl-L-Carnitine, Separately or in Combination, in Patients With Early Chronic Peyronie’s Disease: A Double-Blind, Placebo Controlled, Randomized Study, The Journal of Urology, October 2007, Wolters Kluwer Health,
DOI: 10.1016/j.juro.2007.05.162.
You can read the full text:




The following have contributed to this page