What is it about?
We developed a method for generating artificial signaling networks that were reasonably realistic and thus could be treated as ground truth models. We defined the reaction degree and reaction distance to measure the topology of reaction networks, especially to consider enzymes.
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Why is it important?
These synthetic models could then be used to generate synthetic data for developing and testing algorithms designed to recover the underlying network topology and associated parameters.
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This page is a summary of: Generating synthetic signaling networks for in silico modeling studies, Journal of Theoretical Biology, October 2024, Elsevier,
DOI: 10.1016/j.jtbi.2024.111901.
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