What is it about?

Iron oxide nanoparticles have been used for several years now in anti-cancer approaches because their magnetic properties. However, no intrinsic anti-tumor activity has been described until this publication. Here, we demonstrated that polyethyleneimine-coated iron oxide nanoparticles are able to inhibit pancreatic tumor cell migration which opens a new application for these nanomaterials.

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Why is it important?

Our findings possibilitate the use of these nanoparticles as an anti-metastatic agent independently of their magnetic properties. In addition, highlight the need for studying other nanoparticle`s intrinsic biological activities for their exploitation in cancer treatment.

Perspectives

This paper was the result of a profound collaboration of their authors who wish you can find on it some tools and ideas to exploit your nanomaterials in cancer research.

Dr. Vladimir Mulens-Arias
National Center for Biotechnology, Madrid (CNB-CSIC)

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This page is a summary of: Polyethylenimine-coated SPION exhibits potential intrinsic anti-metastatic properties inhibiting migration and invasion of pancreatic tumor cells, Journal of Controlled Release, October 2015, Elsevier, DOI: 10.1016/j.jconrel.2015.08.009.
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