Heat stress induced histopathology and pathophysiology of the central nervous system

R.G. Ahmed
  • International Journal of Developmental Neuroscience, October 2005, Elsevier
  • DOI: 10.1016/j.ijdevneu.2005.05.005

Heat stress & CNS

What is it about?

The number of reports on the effects of heat stress is still increasing on account of the temperature is one of the most encountered stressful factors on the different biological systems. Because the heat stress (HS) considered a model of thermal injury to the central nervous system (CNS), the purpose of this review was to assess the histopathological changes of HS on CNS. Also, this review emphasized that the heat stress may retard partially the degree of the postnatal neurogenesis and growth of CNS. Taken together, owing to one of the most important functions of heat shock protein is to protect the organisms from the deleterious effects of temperature, thus, it can be hypothesized that the formation of heat shock proteins may be related to the deleterious effect of HS. On the other hands, the alterations of neurotransmitters in the central nervous system might be involved in the physiological and biochemical responses that occur during heat stress. The hypothalamic monoaminergic systems play an important role in the thermoregulation through regulate the heat production and heat dissipation. In addition, the disturbance in the biochemical variables due to the high temperature may be the cause of the histopathological changes and the partial retardation in CNS and the reverse is true. Thus, further studies need to be done to emphasize this concept.

Why is it important?

the current review suggests that, the exposure to high temperature caused some malformation, and from these observations, I can conclude that, the heat stress may delay partially the development of the architecture of the CNS. Thus, there is good reason to suppose that the pathological changes may due to the disturbance in the biochemical variables in CNS regions and the reverse is true.


Ahmed R. G. (Author)
Division of Anatomy and Embryology, Zoology department, Faculty of Science, Beni-Suef University, Egypt.

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The following have contributed to this page: Ahmed R. G.