Deciphering the loss of metal binding due to mutation D83G of human SOD1 protein causing FALS disease

E. Srinivasan, R. Rajasekaran
  • International Journal of Biological Macromolecules, February 2018, Elsevier
  • DOI: 10.1016/j.ijbiomac.2017.09.019

Brain-Related Disease Study

What is it about?

The most important key functioning unit in the human body is the brain. Due to various missense mutations in the proteins present in the brain the patients suffer from distinct brain disease namely, ALS, Parkinson's, Alzheimer's etc.,

Why is it important?

Our findings aid from the computational outlook in projecting the disease case scenario in the patient suffering from brain diseases, its cause, mechanistic action and the overall therapeutic effect of the treating the disorder using naturally obtained polyphenols.

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http://dx.doi.org/10.1016/j.ijbiomac.2017.09.019

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