What is it about?
During infection, pathogens are subjected to important oxidative stress. We have characterized DNA damage (DSB, activation of the DDR) during host-pathogen interactions as well as the importance of base excision repair in order to counteract these lesions. When base excision is impaired, parasites are less infective, more sensitive to DNA damage and up-regulate detoxification systems.
Featured Image
Why is it important?
Our findings emphasize the importance of DNA repair pathways in the protection to genotoxic and oxidative stress in trypanosomes, as well as it provides insights of DNA damage during infection.
Perspectives
I believe that our results provide crucial information about how infection process affects the parasite and parasitic mechanisms to overcome deficiencies in repair pathways.
Miriam Yagüe Capilla
Karolinska Institutet
Read the Original
This page is a summary of: Base excision repair plays an important role in the protection against nitric oxide- and in vivo-induced DNA damage in Trypanosoma brucei, Free Radical Biology and Medicine, February 2019, Elsevier,
DOI: 10.1016/j.freeradbiomed.2018.11.025.
You can read the full text:
Contributors
The following have contributed to this page
