How are mammalian methionine adenosyltransferases regulated in the liver? A focus on redox stress

  • María A. Pajares, Luis Álvarez, Dolores Pérez-Sala
  • FEBS Letters, May 2013, Wiley
  • DOI: 10.1016/j.febslet.2013.04.034

Redox stress regulates production of the main cellular methyl donor S-adenosylmethionine

What is it about?

This manuscript describes a hypothesis of how the synthesis of S-adenosylmethionine is regulated in mammals. Combining in vitro and in vivo data obtained in different laboratories it is possible to produce a whole view of the different regulatory levels at which redox stress acts to modulate the production of this metabolite and, in turn of key methylation events such as epigenetic methylations.

Why is it important?

It offers a whole view of the regulation of S-adenosylmethionine synthesis under normal and pathological conditions that concur with redox stress.


Dr María A Pajares
Centro de Investigaciones Biológicas Margarita Salas (CSIC)

Writing this article helped to obtain an overall view of the importance and impact of redox stress in key metabolic events for any cell.

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The following have contributed to this page: Dr María A Pajares