Redox stress regulates production of the main cellular methyl donor S-adenosylmethionine
What is it about?
This manuscript describes a hypothesis of how the synthesis of S-adenosylmethionine is regulated in mammals. Combining in vitro and in vivo data obtained in different laboratories it is possible to produce a whole view of the different regulatory levels at which redox stress acts to modulate the production of this metabolite and, in turn of key methylation events such as epigenetic methylations.
Why is it important?
It offers a whole view of the regulation of S-adenosylmethionine synthesis under normal and pathological conditions that concur with redox stress.
The following have contributed to this page: Dr María A Pajares