What is it about?
The potentially favorable effects of artichoke leaf extract (ALE) have been shown on lipid profile; however, results are inconsistent. Taq IB polymorphism in cholesteryl ester transfer protein (CETP) gene may modulate the response to intervention. This study examined the effects of ALE supplementation on serum lipid profile and CETP levels regarding CETP Taq IB polymorphism in patients with metabolic syndrome.
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Why is it important?
Our finding indicated that ALE supplementation decreased TG levels without intervention-genotype interaction in patients with MetS. However, men with Taq IB-B1B1 genotype indicated a reduction of LDL-C in response to ALE.
Perspectives
Our results somewhat favor the genotype×intervention interaction, but needs to be proven in a larger sample size with longer intervention duration by consideration of sex differences.
Khatereh Rezazadeh
Nutrition Research Center, School of Nutrition & Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
Read the Original
This page is a summary of: The effect of artichoke leaf extract supplementation on lipid and CETP response in metabolic syndrome with respect to Taq 1B CETP polymorphism: A randomized placebo-controlled clinical trial, European Journal of Integrative Medicine, January 2018, Elsevier,
DOI: 10.1016/j.eujim.2017.12.008.
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