Development of layered PLGA membranes for periodontal tissue regeneration

Itsumi Yoshimoto, Jun-Ichi Sasaki, Ririko Tsuboi, Satoshi Yamaguchi, Haruaki Kitagawa, Satoshi Imazato
  • Dental Materials, March 2018, Elsevier
  • DOI: 10.1016/

Development of layered PLGA membranes for periodontal tissue regeneration.

What is it about?

Various commercial products are available for guided tissue regeneration (GTR) therapy; however, they do not combine biosafety with the ability to control cell function. The purpose of this study was to evaluate the physicochemical and biological characteristics of the novel bilayer biodegradable poly(lactic-co-glycolic acid) (PLGA) membrane, and to assess whether the bilayer PLGA membrane could be used for periodontal tissue regeneration.

Why is it important?

The layering technology used to fabricate the bilayer polymer membrane could be applied in the developing of other novel biomaterials. The present study demonstrates that the bilayer biodegradable polymer membranes facilitate tissue regeneration in vivo, and therefore represent a prospective biomaterial for GTR therapy.

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The following have contributed to this page: Dr Satoshi Yamaguchi