What is it about?

This article explores how scientists are joining different enzymes together to create "fusion proteins" that are more effective than enzymes on their own. By carefully designing these combinations, researchers can make proteins that perform new or improved functions, such as breaking down complex materials, delivering medicines more precisely, or detecting diseases earlier. The review also highlights the latest techniques used to build and test these fusion proteins, and discusses how this approach is opening up new possibilities in medicine, environmental science, and industry. The goal is to help both experts and non-experts understand how fusion proteins are made, why they matter, and what the future may hold for this exciting area of biotechnology.

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Why is it important?

Fusion proteins are transforming what is possible in biotechnology and medicine. By combining the strengths of different enzymes, scientists can create innovative solutions for challenges like sustainable manufacturing, targeted therapies, and advanced diagnostics. This work is timely because it not only summarizes current breakthroughs, but also points to future directions that could lead to more effective treatments, greener technologies, and better tools for research. The insights from this review can inspire new collaborations and accelerate progress in fields ranging from healthcare to environmental protection.

Perspectives

As a researcher in this field, I am excited by how fusion proteins are breaking traditional boundaries in science. The ability to tailor proteins for specific tasks means we can address problems that were previously out of reach. I believe that continued innovation in protein engineering will unlock even greater potential, leading to breakthroughs that benefit society in unexpected ways. Sharing this knowledge widely is essential to spark new ideas and partnerships across disciplines.

Hafiz Muhammad Husnain Azam
Brandenburgische Technische Universitat Cottbus-Senftenberg

Read the Original

This page is a summary of: Fusion of enzymatic proteins: Enhancing biological activities and facilitating biological modifications, Advances in Colloid and Interface Science, June 2025, Elsevier,
DOI: 10.1016/j.cis.2025.103473.
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