Virosomes interfere with Ebola virus control by the immune system
What is it about?
We show that the Ebola virus glycoprotein can be incorporated into non-infectious particles, termed virosomes. Virosomes can serve as antibody decoys and modulate macrophage function. The Interferon induced antiviral host cell protein tetherin inhibits virosome release.
Why is it important?
Our results show that virosomes can interfere with immune control of Ebola virus. Moreover, our findings indicate that tetherin may interfere with Ebola virus spread in two ways: Blockade of release of viral particles and virosomes. Finally, our findings may have implications for antiviral strategies. Thus, virosomes are not infectious and easy to produce and might serve as vaccine candidates.
The following have contributed to this page: Professor Stefan Pöhlmann