Liposome formulation to deliver boron compounds for cancer treatment
Photo by Michael Longmire on Unsplash
What is it about?
Boron Neutron Capture Therapy (BNCT) is a type of radiotherapy where boron-containing compounds are preferentially uptaken by tumour cells and then the area is exposed to a low energy neutron beam (much less damaging than radiotherapy). This causes the boron, located in the cancer cells, to emit a radioactive alpha particle which destroys the cancer cells. Since the alpha particles can only travel about one cell's distance from the boron-containing cancer cells, surrounding normal tissue is unaffected. This paper describes the formulation and stability of nanoparticles, known as liposomes, containing the model boron-containing material, ortho carborane.
Why is it important?
Formulating stable and effective boron-containing compounds is important in the development of Boron Neutron Capture Therapy for treating cancer.
The following have contributed to this page: Dr James R Smith