PI4 Kinase Inhibitors
What is it about?
PI4 Kinase alpha is a biological target that has been implicated in both cancer and infection. Here we describe the discovery and optimisation of a very selective series of inhibitors
Why is it important?
Other inhibitors of this target have also been described. This series of inhibitors is very selective against the alpha form of the enzyme. Having access to a number of different chemical types of inhibitors should help biologists to unravel the precise cellular pathways that PI4 kinase effects
The following have contributed to this page: Dr David M Andrews