Dynamic changes of epigenetic signatures during chondrogenic and adipogenic differentiation of mesenchymal stem cells

  • Navid Saidi, Majdedin Ghalavand, Mohammad Sadegh Hashemzadeh, Ruhollah Dorostkar, Hamed Mohammadi, Ahmad Mahdian-shakib
  • Biomedicine & Pharmacotherapy, May 2017, Elsevier
  • DOI: 10.1016/j.biopha.2017.02.093

Epigenetic signatures in chondrogenic and adipogenic differentiation of mesenchymal stem cells

What is it about?

This review dedicated to addressing the changes of various epigenetic mechanisms, including DNA methylation, histone modifications, and micro-RNAs during chondrogenic and adipogenic differentiation of mesenchymal stem cell.

Perspectives

Hamed Mohammadi

The recent investigations recommend that the link between Adipose-derived stem cells, chondrocytes, and growth factors is a key item that might be beneficial in cartilage repair and tissue engineering. Nonetheless, their capability for cartilage regeneration and exact functional mechanisms of that are still not crystal clear, and several other features like the epigenetic modifications need to be explained in more details. As a result, these regulatory mechanisms must be well understood to shed the light into many ambiguities in the mesenchymal stem cell differentiation processes.

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http://dx.doi.org/10.1016/j.biopha.2017.02.093

The following have contributed to this page: Hamed Mohammadi

Contributors