Hydrogel-based biomimetic environment for in vitro modulation of branching morphogenesis

Hiroyuki Miyajima, Takuya Matsumoto, Takayoshi Sakai, Satoshi Yamaguchi, Sang Hyun An, Makoto Abe, Satoshi Wakisaka, Kuen Yong Lee, Hiroshi Egusa, Satoshi Imazato
  • Biomaterials, October 2011, Elsevier
  • DOI: 10.1016/j.biomaterials.2011.05.072

Hydrogel-based biomimetic environment for in vitro modulation of branching morphogenesis

What is it about?

We explain here that the physical properties of the cell and tissue microenvironment, biomimetically reproduced by using hydrogel, guide the tissue morphogenesis in the developmental submandibular gland (SMG). In particular, the softer gel enhances the bud expansion and cleft formation of SMG, whereas the stiffer gel attenuates them.

Why is it important?

Our findings suggest that cells sense the mechanics of their surrounding environment and alter their properties for self-organization and the following tissue morphogenesis. Also, physically designed hydrogel material is a valuable tool for producing the biomimetic microenvironment to explore how physical cues affect tissue morphogenesis and to modulate tissue morphogenesis for in vitro tissue synthesis.

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The following have contributed to this page: Dr Satoshi Yamaguchi