What is it about?

This study investigates the role of microRNAs in premature deterioration of endothelial cells. It was proven in this study that the downregulation of the MTORC1 pathway can delay the onset of cell deterioration. The specific miRNA which is involved in the inhibition of this pathway is identified as miRNA-107. The increase in miRNA-107 expression leads to the rise of MTORC1 activities which prompts cell senescence. On the other hand, the decrease of miRNA-107 via long-term low dose rapamycin delays senescence. Thus, through further applied and translational studies, this discover could benefit global aging population by reducing risks of aging-related diseases.

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Why is it important?

By understanding the mechanism of endothelial senescence, age-related vascular diseases such as cardiovascular diseases and atherosclerosis can also be prevented. The discovery of this study can also help in developing RNA-based therapies besides the identification of new targets in disease intervention. This is especially beneficial as age-related diseases are on the rise alongside the increasing numbers of aging population all over the world due to medical and technological advancement.


Cellular senescence can be defined as the biological aging of the cell where the cell’s functionality gradually deteriorates. Cellular senescence affects the ability of cells to divide and proliferate. Numerous studies have been done to investigate the process of aging. At the cellular level, aging can be prevented by the inhibition of MTORC1 pathway. The mechanism of this process involves microRNA which regulates cell functions. In line with UN’s third Sustainable Development Goal, an in-depth comprehension of this process can contribute in innovative strategies that can counter premature senescence aiding the aging population in preserving not just good health but also good well-being.

Pooi-Fong Wong
University of Malaya

Read the Original

This page is a summary of: Endothelial replicative senescence delayed by the inhibition of MTORC1 signaling involves MicroRNA-107, The International Journal of Biochemistry & Cell Biology, August 2018, Elsevier,
DOI: 10.1016/j.biocel.2018.05.016.
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