Quercetin conjugated with silica nanoparticles inhibits tumor growth in MCF-7 breast cancer cell lines

  • Fahimeh Aghapour, Ali Akbar Moghadamnia, Andrea Nicolini, Seydeh Narges Mousavi Kani, Ladan Barari, Payam Morakabati, Leyla Rezazadeh, Sohrab Kazemi
  • Biochemical and Biophysical Research Communications, April 2018, Elsevier
  • DOI: 10.1016/j.bbrc.2018.04.174

What is it about?

Background: Quercetin is a plant polyphenol from the flavonoid group that plays a fundamental role in controlling homeostasis due to its potent antioxidant properties. However, quercetin has extremely low water solubility, which is a major challenge in drug absorption. Method: In this study, we described a simple method for the synthesis of quercetin nanoparticles. The quercetin nanoparticles had an average diameter of 82 nm and prominent yellow emission under UV irradiation. Therefore, we used an in vitro model treated with quercetin and quercetin nanoparticles to investigate the effects of quercetin nanoparticles on MCF-7 breast cancer cell line. Finding: MCF-7 cells were cultured with different concentrations (1 to 100 μM) of quercetin nanoparticles at the 24th, 48th and 72nd hours, and cell cycle and apoptosis assays were detected by flow cytometry (FCM). In this study, we found that quercetin nanoparticles (1 to 100 μM) could significantly reduce cell vitality, growth rate and colony formation of MCF-7 cells. Conclusion: Quercetin nanoparticles can inhibit cell growth by blocking the cell cycle and promoting apoptosis in MCF-7 cells more than quercetin. As a result, quercetin nanoparticles may be useful therapy or prevention on breast cancer.

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http://dx.doi.org/10.1016/j.bbrc.2018.04.174

The following have contributed to this page: Sohrab Kazemi

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