What is it about?

Menopause can lead to heightened anxiety and depression-like symptoms in women. The flavonoid chrysin has been shown to diminish these effects. We show that these effects of chrysin are related to the neurotransmitter GABA, which has been shown to respond to sex steroids (such as progesterone and estrogen) and to be associated with anxiety.

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Why is it important?

We show for the first time the mechanism of action of a flavonoid in ameliorating symptoms of depression in an animal model of menopause. Thus, the use of chrysin in menopause is strengthened.

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This page is a summary of: Involvement of GABAergic system in the antidepressant-like effects of chrysin (5,7-dihydroxyflavone) in ovariectomized rats in the forced swim test: comparison with neurosteroids, Behavioural Brain Research, May 2020, Elsevier, DOI: 10.1016/j.bbr.2020.112590.
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