What is it about?

We studied the places of contact between the various machines that transform biological energy. These paired locations, mapped precisely to the parts that contact each other, provide a glimpse of the topology of these machines while they're in action, and how they could coordinate with each other.

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Why is it important?

Nobody knows how these molecular machines talk to one another to synchronize their work - even though transforming energy is the most essential task for molecules to come to life.


When I presented this work in Italy, to some big wigs in the bioenergetics field, it was the first (!) unveiling of pairwise residue-level proximal sites between respiratory complexes, taken from live mitochondria. Accomplishing this feat was a milestone for the field, and a high point in my career. I really do believe that this work will have a subtle (perhaps unnoticeable) but meaningful (perhaps essential) impact on all sorts of research discoveries.

Dr Beverley M. (Dancy) Rabbitts
Washington State University

Read the Original

This page is a summary of: The mitochondrial interactome visualized by crosslinking mass spectrometry, Biochimica et Biophysica Acta (BBA) - Bioenergetics, August 2016, Elsevier, DOI: 10.1016/j.bbabio.2016.04.045.
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