High-plasticity mesenchymal stem cells isolated from adult-retained primary teeth and autogenous adult tooth pulp—A potential source for regenerative therapies?

E. Kushnerev, S.G. Shawcross, M.C. Hillarby, J.M. Yates
  • Archives of Oral Biology, February 2016, Elsevier
  • DOI: 10.1016/j.archoralbio.2015.11.009

Cell plasticity Dental pulp stem cells

What is it about?

The objective of this study was to compare the growth rate, morphology, immunohistology and plasticity of autogenous adult-retained SHEDs (arSHEDs) and adult dental pulp stem cells (DPSCs) obtained from the same donor.

Why is it important?

The SHED and DPSCs have been shown to express mesenchymal stem cell markers, but it is not clear if both types of stem cells from the same human donor will share the same markers, morphology, immunohistology and plasticity. The investigation of the ability of SHED and DPSCs is significant to the field of regenerative endodontics where these cells are needed to regenerate immature teeth, and also for research into the bioengineering of teeth and dental tissues. Hence the need for this study to investigate and compare SHED and DPSCs obtained from the same human donor.


Mr Evgeny Kushnerev

This study demonstrates the similarities between DPSCs and arSHEDs in a unique situation, where both stem cells (SC) types were obtained from a single patient and thus represent an alternative source of SC’s for tissue engineering and regeneration.

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The following have contributed to this page: Mr Evgeny Kushnerev