Adenosine triphosphate analogs can efficiently inhibit the Zika virus RNA-dependent RNA polymerase

  • Kamil Hercík, Jaroslav Kozak, Michal Šála, Milan Dejmek, Hubert Hřebabecký, Eva Zborníková, Miroslav Smola, Daniel Ruzek, Radim Nencka, Evzen Boura
  • Antiviral Research, January 2017, Elsevier
  • DOI: 10.1016/j.antiviral.2016.11.020

ATP analogs that inhibit Zika virus RNA polymerase

What is it about?

We succeeded (as the first academic lab) in purification of active Zika polymerase and we discovered ATP analogs that inhibit this enzyme.

Why is it important?

Our ATP analogs can be converted to prodrugs that could be directly used to combat Zika virus.

Perspectives

Evzen Boura
Institute of Organic Chemistry and Biochemistry

This was our first article about a viral polymerase. Our lab is new in this field, therefore, I am especially glad that we were the first lab to purify active Zika polymerase.

Read Publication

http://dx.doi.org/10.1016/j.antiviral.2016.11.020

The following have contributed to this page: Evzen Boura