What is it about?
Components of the trypanothione-dependent antioxidant system are potential chemotherapeutic targets to develop specific drugs. This system needs a current NADPH supply to provide glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase.
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Why is it important?
heterogeneity among T. cruzi strains and the relationship between resistance to oxidative stress and G6PD activity
Perspectives
Further studies to evaluate the possibility of developing drugs for the treatment of Chagas disease, considering that conventional treatment is unsatisfactory due to limited efficacy and toxic side effects.
Dr. Jorge A. López
Read the Original
This page is a summary of: Trypanosoma cruzi strains, Tulahuen 2 and Y, besides the difference in resistance to oxidative stress, display differential glucose-6-phosphate and 6-phosphogluconate dehydrogenases activities, Acta Tropica, January 2007, Elsevier,
DOI: 10.1016/j.actatropica.2006.12.001.
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