What is it about?
In trying to find fibrin degrading proteases, non-plasmin proteases such as human leukocyte elastase, cathepsin G and α-chymotrypsin were found in spleen. Subsequently, inhibitors to these non-plasmin protease were investigated. Eglin C was selected as playing an important role. Next, the active site or structure of Eglin C was examined by making various synthetic substances peptide. This article describes the results.
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Why is it important?
Fibrin degradation cannot be explained only by plasmin. Other way by plasmin became enabled to treat abnormal fibrin deposing diseases.
Read the Original
This page is a summary of: Synthesis of a trihexacontapeptide corresponding to the sequence 8-70 of eglin c and studies on the relationship between the structure and the inhibitory activity against human leukocyte elastase, cathepsin G and α-chymotrypsin, FEBS Letters, October 1990, Wiley, DOI: 10.1016/0014-5793(90)80461-q.
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