What is it about?
This study explores how tissue surfaces change during two different healing processes: repair of the corneal epithelium and remodelling of arteries affected by atherosclerosis. Scanning electron microscopy was used to examine these changes in three dimensions and to evaluate a semi-quantitative method for describing their severity. The corneal observations showed progressive epithelial migration and eventual wound closure, while the vascular images demonstrated changes ranging from intact endothelium to platelet adhesion, plaque disruption, and thrombus formation. Both tissues were consistent with an early provisional fibrin scaffold followed by different patterns of remodelling.
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Why is it important?
Wound healing is often studied separately in different tissues. By examining corneal repair and atherosclerotic vascular remodelling using a common scanning electron microscopy protocol, this study highlights both shared and tissue-specific morphological changes. It also evaluates a structured semi-quantitative approach that may help make SEM observations more consistent and reproducible. The findings provide a foundation for larger studies using predefined sampling and external validation.
Perspectives
Scanning electron microscopy can reveal surface changes that may be difficult to appreciate using conventional two-dimensional methods. In my view, combining detailed SEM imaging with structured assessment could help move morphological research from description toward more reproducible comparison. Future research should test this framework in larger independent cohorts, use predefined image-selection methods, and evaluate whether the observed patterns are consistent across laboratories and clinical settings.
Prof. Dr. Hesham N. Mustafa
King Abdulaziz University
Read the Original
This page is a summary of: Scanning Electron Microscopy of Corneal and Vascular Wound Healing: A Comprehensive Morphological Study, Bratislava Medical Journal, July 2026, Springer Science + Business Media,
DOI: 10.1007/s44411-026-00787-9.
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