What is it about?
Transcription factors and RNA-binding proteins are among the major classes of regulatory proteins influencing gene expression patterns. These regulatory proteins may interact with/influence each other, thereby adding additional layers of regulation of the downstream genes. The present study aimed at identifying such regulatory inter-connections affecting adult hippocampal neurogenesis (AHN) in mice using computational methods.
Featured Image
Photo by Bhautik Patel on Unsplash
Why is it important?
Understanding the complex molecular cross-talk would be important for a holistic understanding of the molecular basis of AHN.
Perspectives
This study suggests an interaction between a major group of epigenetic/transcriptional regulators - the polycomb proteins, and SRSF1, a dominant RNA-binding protein, influencing AHN. Further experimental studies in this regard would add to our current understanding of the molecular underpinnings of AHN.
Dr Nishanth M J
St Joseph's University
Read the Original
This page is a summary of: Computational analysis of crosstalk between transcriptional regulators and RNA-binding proteins suggests mutual regulation of polycomb proteins and SRSF1 influencing adult hippocampal neurogenesis, Discover Mental Health, March 2023, Springer Science + Business Media,
DOI: 10.1007/s44192-023-00034-5.
You can read the full text:
Contributors
The following have contributed to this page
