What is it about?
The findings confirm that men's stress-related neuroendocrine-immunological interactions affect seminal plasma composition, which in turn is associated with IVF/ICSI outcomes in women exposed to their partner's seminal plasma during an IVF/ICSI cycle.
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Why is it important?
The coordinated activation of the sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenocortical (HPA) system during male sexual activity is essential for maintaining the balanced composition of seminal plasma. This activation is associated with a higher probability of pregnancy in patients who have had contact with seminal plasma during IVF/ICSI cycles. On the other hand, hypofunction of the HPA system, accompanied by hyperactivation of SNS and an imbalance in stress biomarkers in seminal plasma, can lead to a lower probability of pregnancy.
Perspectives
The effectiveness of IVF/ICSI can be increased through the personalized use of seminal plasma.
Marina Nikolaeva
National Medical Research Center for Obstetrics, Gynecology and Perinatology of Ministry of Healthcare of Russian Federation
Read the Original
This page is a summary of: Stress Biomarkers Transferred Into the Female Reproductive Tract by Seminal Plasma Are Associated with ICSI Outcomes, Reproductive Sciences, February 2024, Springer Science + Business Media,
DOI: 10.1007/s43032-024-01486-y.
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