What is it about?
The article list reasons why currently used blood antibody tests are not quantitative in the physical sense and suggests solutions. Real quantitative measurement have SI units, thus, serological assays should have units of energy (binding energy), concentration (antibody or antigen) instead of arbitrary units. While application-oriented testing (medical diagnostics) may accept arbitrary units, the introduction of real quantitation could advance our understanding of the immune system and improve mediacl diagnostics on the long term.
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Why is it important?
Without real quantitative antibody tests we will not be able to understand the immune system as a funtional, integrated system. Treating these measurement as though they were unrelated and independent is misleading and should be solved.
Perspectives
Technologically we are ready to develop truely quantitative serological assays, it is important that scientist understand the need for it.
József Prechl
Diagnosticum
Read the Original
This page is a summary of: Why current quantitative serology is not quantitative and how systems immunology could provide solutions, Biologia Futura, February 2021, Springer Science + Business Media,
DOI: 10.1007/s42977-020-00061-1.
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