Review on Synthetic aspects and pharmacological potential of pyrazole derivatives

What is it about?

There is an increase in infectious diseases every year. Heterocyclic compounds have been in use as drugs for a long time. Amongst many heterocyclic derivatives, the drugs containing the pyrazole core has been in limelight because of its relative ease of synthesis and excellent biological activities. Pyrazoles are aromatic compounds consisting of ring structure where two nitrogen atoms are adjacent to each other and contain three carbon atoms. Over the years pyrazoles have been explored for a variety of pharmacological applications. Herein, this review overviews the information related to industrially important pyrazoline scaffolds and their applications, recent literature on synthesizing the pyrazole derivatives, providing an explanation for their biological activity by focusing on their structural activity relationship and hence affording ideas to design the compounds containing pyrazole scaffolds.

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Why is it important?

Brief discussion on the synthesis of pyrazoles in different methods using conventional methods, green methods and Deep eutectic solvents. Pharmacological activity like antimicrobial activity, anticancer, anti-inflammatory and others. Discussion on structure activity relationship for better understanding of molecular structure and biological activity.