What is it about?
The paper involved the development and analysis of vaccine constructs targeting Shamonda virus, a member of Orthobunya viruses, which are transmitted by Culicoides species and affect hosts like Bos taurus (cattle). The study involves computational methods, including ProteinSol analysis, SOPMA server for secondary structure prediction, and Ramachandran plots for structural validation. It evaluates the physicochemical properties, solubility, and stability of six vaccine constructs. The constructs incorporate adjuvants such as high mobility group protein B1 (HMGPB1), beta-defensin 1 (BD1), and beta-synuclein (BS) for mammals, along with HTL, CTL, and LBL epitopes.
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Why is it important?
The study aims to provide insights into the design of effective vaccines against Orthobunya viruses, for which no vaccines currently exist.
Read the Original
This page is a summary of: Genomic insights and immunoinformatics-driven design of a multi-epitope subunit vaccine candidate against Shamonda virus, In Silico Pharmacology, November 2025, Springer Science + Business Media,
DOI: 10.1007/s40203-025-00460-z.
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