What is it about?
Solitary extrahepatic hepatocellular carcinoma without a primary lesion in the liver is rare and unique. In such patients, in addition to hepatocellular carcinoma, hepatoid adenocarcinoma, hepatoid teratoma, and hepatoid yolk sac tumor must be considered as differential diagnoses, and patients must be investigated in detail by histopathological studies with immunohistochemistry, especially using epithelial markers for which tumor cells are generally negative in hepatocellular carcinoma. A case with a solitary neoplasm of the vertebrae, which was diagnosed histopathologically as hepatocellular carcinoma, without a primary lesion is presented. The primary lesion was not identified even on autopsy, and the liver was pathologically almost normal.
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Why is it important?
Given the review of the literature and circumstantial evidence, we would like to propose a bold new hypothesis that hepatocellular carcinoma might primarily originate from bone marrow.
Perspectives
This review provides the answer to a question published on Letters to the editor of the American Journal of Gastroenterology in 1998 (Reference 7), "What could be the etiopathogenic hypothesis: an ectopia of liver cells, or a metastasis of microhepatocellular carcinoma destroyed by the immune system?"
Yukihiro Shirota
Saiseikai Kanazawa Hospital
Read the Original
This page is a summary of: Solitary extrahepatic hepatocellular carcinoma in vertebrae without a primary lesion in the liver might originate from bone marrow: a case report and new hypothesis based on a review of the literature and the latest findings, Clinical Journal of Gastroenterology, September 2022, Springer Science + Business Media,
DOI: 10.1007/s12328-022-01701-w.
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