What is it about?
This article outlines how an inflammatory factor (IL-6) expressed in breast tissue adjacent to the growing tumour (the stroma) can promote tumour aggressiveness.
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Perspectives
This was a highly rewarding study, in which for the first time (for me) I applied species specific real-time PCR gene expression to assess contribution of stromally expressed (murine) and tumourally expressed (human) genes in murine xenografts. It was also a prelude to my 2015 review on inflammation contribution to carcinogenesis.
Dr Honor J Hugo
Queensland University of Technology
Read the Original
This page is a summary of: Contribution of Fibroblast and Mast Cell (Afferent) and Tumor (Efferent) IL-6 Effects within the Tumor Microenvironment, Cancer Microenvironment, February 2012, Springer Science + Business Media,
DOI: 10.1007/s12307-012-0098-7.
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