Regulatory characteristics of Vibrio vulnificus iscR

What is it about?

This paper is about regulation of iscR gene encoding the Fe-S cluster regulator IscR via IscR itself and AphA, a quorum sensing regulator that operates in low cell density.

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Why is it important?

Low cell density regulator AphA upregulates iscR expression by antagonizing its negative autoregulation. It is noteworthy that the iscR expression is upregulated by AphA at low cell density since, during the initial stage of infection, the low cell density leads to the production of IscR, a global regulator which is important to the pathogenesis.